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Katharine L Chu Selected Research

Freund's Adjuvant

6/2014A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.
4/2014Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
7/2013Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats.
3/2012TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation.
10/2010Characterization of Fasudil in preclinical models of pain.
12/2008Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.
9/2008(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.
1/2006Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.
11/2004Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity.

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Katharine L Chu Research Topics

Disease

13Pain (Aches)
10/2018 - 10/2002
11Hyperalgesia
06/2014 - 10/2002
5Neuralgia (Stump Neuralgia)
06/2014 - 12/2003
4Inflammation (Inflammations)
08/2012 - 10/2002
3Chronic Pain
06/2014 - 03/2008
2Wounds and Injuries (Trauma)
02/2018 - 11/2004
1Neoplasms (Cancer)
01/2018
1Fatigue
01/2018
1Osteoarthritis
07/2013
1Hypersensitivity (Allergy)
10/2010
1Nociceptive Pain
10/2010
1Acute Pain
10/2010
1Ganglion Cysts (Ganglion)
01/2006
1Peripheral Nerve Injuries
12/2003

Drug/Important Bio-Agent (IBA)

9Freund's AdjuvantIBA
06/2014 - 11/2004
4CarrageenanIBA
06/2014 - 10/2002
4TRPV1 receptorIBA
03/2012 - 10/2003
3Iodoacetic AcidIBA
02/2018 - 10/2010
3Analgesics (Analgesic Drugs)IBA
04/2014 - 10/2010
3A-889425IBA
03/2012 - 12/2008
2N2- methyl- N- ((2- (4- (trifluoromethyl)phenyl)octahydrocyclopenta(c)pyrrol- 4- yl)leucinamideIBA
04/2014 - 01/2014
2A-317491IBA
08/2012 - 12/2003
2Capsaicin (Zostrix)FDA Link
10/2010 - 10/2003
1PlasticsIBA
02/2018
12-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
02/2018
1depatuxizumab mafodotinIBA
01/2018
1ErbB Receptors (EGF Receptor)IBA
01/2018
1Immunoconjugates (Immunoconjugate)IBA
01/2018
1Monoclonal AntibodiesIBA
01/2018
1Cytotoxins (Cytolysins)IBA
01/2018
1T-Type Calcium Channels (T-Type Calcium Channel)IBA
06/2014
14- chloro- 2- fluoro- N- (2- fluorophenyl)- 5- (hexahydropyrrolo(1,2- a)pyrazin- 2(1H)- ylcarbonyl)benzenesulfonamideIBA
06/2014
1Mitogen-Activated Protein Kinase 3IBA
04/2014
1Biomarkers (Surrogate Marker)IBA
04/2014
1Histamine (Histamine Dihydrochloride)FDA Link
10/2012
1A 967079IBA
05/2011
1Pharmaceutical PreparationsIBA
05/2011
1allyl isothiocyanateIBA
05/2011
1TRPV Cation ChannelsIBA
05/2011
1ABT 102IBA
05/2011
1TRPA1 Cation ChannelIBA
05/2011
1fasudil (AT 877)IBA
10/2010
1rho-Associated KinasesIBA
10/2010
1CationsIBA
09/2008
1Sodium Channel BlockersIBA
03/2008
1A 803467IBA
03/2008
1furanIBA
03/2008
11- isoquinolin- 5- yl- 3- (4- trifluoromethyl- benzyl)- ureaIBA
01/2006
1salicylhydroxamic acid (SHAM)IBA
11/2004
1NucleotidesIBA
12/2003
1capsazepineIBA
10/2003
1Neurotransmitter Agents (Neurotransmitter)IBA
10/2002
1Adenosine KinaseIBA
10/2002
1N(6)-cyclopentyladenosineIBA
10/2002
1Purinergic P1 Receptor AgonistsIBA
10/2002
1Adenosine-5'-(N-ethylcarboxamide) (NECA)IBA
10/2002
1NucleosidesIBA
10/2002
1Adenosine (Adenocard)FDA LinkGeneric
10/2002
1beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA
10/2002
12- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosineIBA
10/2002

Therapy/Procedure

4Ligation
01/2014 - 12/2003
3Injections
01/2017 - 12/2003
2Oral Administration
06/2014 - 04/2014
1Therapeutics
10/2018